Atlixco (Nahuatl pronunciation: [aːˈt͡ɬiːʃko] (listen)) is a city in the Mexican state of Puebla. It is a regional industrial and commercial center but economically it is much better known for its production of ornamental plants and cut flowers. The city was founded early in the colonial period, originally under the jurisdiction of Huejotzingo, but eventually separated to become an independent municipality. The municipality has a number of notable cultural events, the most important of which is the El Huey Atlixcayotl, a modern adaptation of an old indigenous celebration. This event brings anywhere from 800 to 1,500 participants from all over the state of Puebla to create music, dance, and other cultural and artistic performances. Atlixco joined the UNESCO Global Network of Learning Cities in 2018.